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产品编号	产品名称	产品包装	产品价格
C1062S	Annexin V-FITC细胞凋亡检测试剂盒	20次	616.00元
C1062M	Annexin V-FITC细胞凋亡检测试剂盒	50次	1098.00元
C1062L	Annexin V-FITC细胞凋亡检测试剂盒	100次	1566.00元

Annexin V-FITC细胞凋亡检测试剂盒(Annexin V-FITC Apoptosis Detection Kit)是用FITC标记的重组人Annexin V来检测细胞凋亡时出现在细胞膜表面的磷脂酰丝氨酸的一种细胞凋亡检测试剂盒。可以使用流式细胞仪、荧光显微镜或其它荧光检测设备进行检测。
Annexin是一类广泛分布于真核细胞细胞浆内钙离子依赖的磷脂结合蛋白，参与细胞内的信号转导。但仅Annexin V被报道可以调控一些PKC的活性。
Annexin V选择性结合磷脂酰丝氨酸(phosphatidylserine，简称PS)。磷脂酰丝氨酸主要分布在细胞膜内侧，即与细胞浆相邻的一侧。在细胞发生凋亡的早期，不同类型的细胞都会把磷脂酰丝氨酸外翻到细胞表面，即细胞膜外侧。磷脂酰丝氨酸暴露到细胞表面后会促进凝血和炎症反应。而Annexin V和外翻到细胞表面的磷脂酰丝氨酸结合后可以阻断磷脂酰丝氨酸的促凝血和促炎症反应活性。
用带有绿色荧光的荧光探针FITC标记的Annexin V，即Annexin V-FITC，就可以用流式细胞仪或荧光显微镜非常简单而直接地检测到磷脂酰丝氨酸的外翻这一细胞凋亡的重要特征。
本试剂盒还提供了碘化丙啶(Propidium Iodide, PI)染色液，碘化丙啶可以染色坏死细胞或凋亡晚期丧失细胞膜完整性的细胞，呈现红色荧光。对于坏死细胞，由于细胞膜的完整性已经丧失，Annexin V-FITC可以进入到细胞浆内，与位于细胞膜内侧的磷脂酰丝氨酸结合，从而也使坏死细胞呈现绿色荧光。
本试剂盒的流式检测效果参考图1和图2，荧光显微镜检测效果参考图3。

 

 

图1.细胞用本试剂盒染色后流式细胞仪检测细胞凋亡的效果图。Jurkat细胞未经处理(A)或用10μM喜树碱(Camptothecin)作用4小时(B)后，用本试剂盒染色，然后用流式细胞仪进行细胞的散射和荧光检测。从图中可以看出，经过凋亡诱导剂喜树碱处理后的细胞，其Annexin V-FITC染色阳性并且PI染色阴性的细胞，即凋亡细胞，明显增加(B图的右下象限)，Annexin V-FITC和PI染色双阳性的细胞，即坏死细胞，也有所增加(B图的右上象限)。图中Annexin V-FITC染色阴性PI染色阳性(Annexin V-/PI+)所在象限(A和B图的左上象限)出现的细胞点是许可范围内的检测误差。实测数据可能会因细胞类型、细胞凋亡情况、检测仪器等的不同而存在差异，图中数据仅供参考。

 

 

图2.细胞用本试剂盒染色后流式细胞仪检测效果验证图。Jurkat细胞用10μM喜树碱(Camptothecin)作用4小时后，未经染色(A)、仅用本试剂盒中的PI进行染色(B)、仅用本试剂盒中的Annexin V-FITC进行染色(C)、用本试剂盒中的Annexin V-FITC和PI进行双染(D)。从图中可以看出，未经染色的是双阴性细胞(A)，仅PI染色后出现了预期的PI染色阳性的细胞，仅Annexin V-FITC染色出现了预期的Annexin V-FITC染色阳性的细胞，Annexin V-FITC和PI双染出现了预期的仅Annexin V-FITC染色阳性的凋亡细胞和双阳性的坏死细胞。出现的非预期的细胞点完全在许可的误差范围内。实测数据可能会因细胞类型、细胞凋亡情况、检测仪器等的不同而存在差异，图中数据仅供参考。

本试剂盒小包装C1062S可以检测20个样品，中包装C1062M可以检测50个样品，大包装C1062L可以检测100个样品。
包装清单：

产品编号	产品名称	包装
C1062M-1	Annexin V-FITC	250μl
C1062M-2	Annexin V-FITC结合液	30ml
C1062M-3	碘化丙啶染色液	550μl
—	说明书	1份

保存条件：
4℃保存，半年有效。-20℃保存，一年有效。Annexin V-FITC和碘化丙啶染色液需要避光保存。为了长期保存，可以把碘化丙啶染色液适当分装后-20℃保存。
注意事项：
尽管经测试Annexin V-FITC反复冻融5次对于其检测效果无显著影响，但为取得良好的使用效果，3-6个月内推荐4℃保存，并适当注意避免反复冻融。
如果有细菌或真菌污染，会严重影响检测效果。
染色后宜尽快检测，时间过长可能会导致凋亡或坏死细胞的数量增加。
如果细胞收集过程中使用了胰酶，需注意设法去除残留的胰酶。残留的胰酶会消化并降解Annexin V-FITC，导致染色失败。
荧光物质均易发生淬灭，在进行荧光观察时，尽量缩短观察时间，同时在操作和存放过程中也尽量注意避光保存。
用于流式细胞仪检测时，如果发现Annexin V-FITC单独染色时出现了过多的PI假阳性细胞，并且通过调整相关设置和参数也无法改善，可以用PBS将Annexin V-FITC稀释3-10倍后再进行检测，这样通常可以有效减少假阳性的坏死细胞。
需自备PBS。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

 

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3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway.
Apoptosis . 2012 Jul;17(7):725-34. (IF 4.021)
59. Li P, Wang K, Zhang J, Zhao L, Liang H, Shao C, Sutherland LC.
The 3p21.3 tumor suppressor RBM5 resensitizes cisplatin-resistant human non-small cell lungcancer cells to cisplatin.
Cancer Epidemiol . 2012 Oct;36(5):481-9. (IF 2.619)
60. Lin F, Lin P, Zhao D, Chen Y, Xiao L, Qin W, Li D, Chen H, Zhao B, Zou H, Zheng X, Yu X.
Sox2 targets cyclinE, p27 and survivin to regulate androgen-independent human prostate cancercell proliferation and apoptosis.
CELL PROLIFERAT . 2012 Jun;45(3):207-16. (IF 5.039)
61. Sun T, Zheng W, Peng H, Zhang A, Chen Y, Tan R, Shen P.
A small molecule IFB07188 inhibits proliferation of human cancer cells by inducing G2/M cell cycle arrest and apoptosis.
Biomed Pharmacother . 2012 Oct;66(7):512-8. (IF 3.743)
62. Zhu S, Wang Y, Jin J, Guan C, Li M, Xi C, Ouyang Z, Chen M, Qiu Y, Huang M, Huang Z.
Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renalproximal tubular epithelial cells.
Toxicol In Vitro . 2012 Aug;26(5):663-71. (IF 3.067)
63. Zhao D, Lin F, Wu X, Zhao Q, Zhao B, Lin P, Zhang Y, Yu X.
Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells.
Toxicol In Vitro . 2012 Jun;26(4):595-602. (IF 3.067)
64. Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, Yuan J.
MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediatedmitochondria-dependent signaling pathway.
Food Chem Toxicol . 2012 Jul;50(7):2424-31. (IF 3.775)
65. Qi L, Wu P, Zhang X, Qiu Y, Jiang W, Huang D, Liu Y, Tan P, Tian Y.
Inhibiting ERp29 expression enhances radiosensitivity in human nasopharyngeal carcinoma celllines.
Med Oncol . 2012 Jun;29(2):721-8. (IF 3.252)
66. Shi G, Zhang Z, Zhang R, Zhang X, Lu Y, Yang J, Zhang D, Zhang Z, Li X, Ning G.
Protective effect of andrographolide against concanavalin A-induced liver injury.
N-S ARCH PHARMACOL . 2012 Jan;385(1):69-79. (IF 2.058)
67. Wang C, Sheng G, Lu J, Xie L, Bai S, Wang Y, Liu Y.
Effect of RNAi-induced down regulation of nuclear factor kappa-B p65 on acute monocyticleukemia THP-1 cells in vitro and vivo.
Mol Cell Biochem . 2012 Jan;359(1-2):125-33. (IF 2.884)
68. Du P, Hu S, Cheng Y, Li F, Li M, Li J, Yi L, Feng H.
Photodynamic therapy leads to death of C6 glioma cells partly through AMPAR.
Brain Res . 2012 Jan 18;1433:153-9. (IF 2.929)
69. Wang X, Wu H, Chen H, Liu R, Liu J, Zhang T, Yu W, Hai C.
Does insulin bolster antioxidant defenses via the extracellular signal-regulated kinases-protein kinase b-nuclear factor erythroid 2 p45-related factor 2 pathway.
ANTIOXID REDOX SIGN . 2012 May 15;16(10):1061-70. (IF 5.828)
70. Zhang Y, Luo M, Zu Y, Fu Y, Gu C, Wang W, Yao L, Efferth T.
Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway.
CHEM-BIOL INTERACT . 2012 Aug 30;199(2):129-36. (IF 3.407)
71. Liu S, Ma X, Ai Q, Huang Q, Shi T, Zhu M, Wang B, Zhang X.
NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renalcell carcinoma.
UROL ONCOL-SEMIN ORI . 2013 Aug;31(6):938-48. (IF 2.863)
72. Chen T, Hao J, He J, Zhang J, Li Y, Liu R, Li L.
Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest inHepG2 cells.
Food Chem . 2013 Jun 1;138(2-3):1034-41. (IF 5.399)
73. Chen X, Du Y, Nan J, Zhang X, Qin X, Wang Y, Hou J, Wang Q, Yang J.
Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells.
PLoS One . 2013 May 21;8(5):e63697. (IF 2.776)
74. Zhang JF, Zhang JG, Kuai XL, Zhang H, Jiang W, Ding WF, Li ZL, Zhu HJ, Mao ZB.
Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2'-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells.
Exp Ther Med . 2013 Mar;5(3):735-741. (IF 1.448)
75. Du XX, Li YJ, Wu CL, Zhou JH, Han Y, Sui H, Wei XL, Liu L, Huang P, Yuan HH, Zhang TT, Zhang WJ, Xie R, Lang XH, Jia DX, Bai YX.
Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin.
Biomed Pharmacother . 2013 Jun;67(5):417-24. (IF 3.743)
76. Song T, Xue Z, Zhang Z, Shen X, Li X.
Pan-BH3 Mimetic S1 Exhibits Broad-Spectrum Antitumour Effects by Cooperation between Bax and Bak.
BASIC CLIN PHARMACOL . 2013 Sep;113(3):145-51. (IF 2.452)
77. Gu G, Gao X, Hu Q, Kang T, Liu Z, Jiang M, Miao D, Song Q, Yao L, Tu Y, Pang Z, Chen H, Jiang X, Chen J.
The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugatednanoparticles on glioma cells.
Biomaterials . 2013 Jul;34(21):5138-48. (IF 10.273)
78. Tang Q, Li G, Wei X, Zhang J, Chiu JF, Hasenmayer D, Zhang D, Zhang H.
Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma.
Cancer Lett . 2013 Aug 19;336(2):325-37. (IF 6.508)
79. Wang Y, Liu P, Qiu L, Sun Y, Zhu M, Gu L, Di W, Duan Y.
Toxicity and therapy of cisplatin-loaded EGF modified mPEG-PLGA-PLL nanoparticles for SKOV3 cancer in mice.
Biomaterials . 2013 May;34(16):4068-77. (IF 10.273)
80. Cheng P, Ni Z, Dai X, Wang B, Ding W, Rae Smith A, Xu L, Wu D, He F, Lian J.
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in humanhepatocellular cells.
Cell Death Dis . 2013 Feb 7;4:e489. (IF 5.959)
81. Tang S, Gao D, Zhao T, Zhou J, Zhao X.
An uation of the anti-tumor efficacy of oleanolic acid-loaded PEGylated liposomes.
Nanotechnology . 2013 Jun 14;24(23):235102. (IF 3.399)
82. Zhu K, Guo X, Guo X, Peng W, Zhou H.
Protective effects of wheat germ protein isolate hydrolysates (WGPIH) against hydrogen peroxide-induced oxidative stress in PC12 cells.
Food Research International .2013 Aug;53(1):297-303. (IF 3.579)
83. Hu Q, Gao X, Gu G, Kang T, Tu Y, Liu Z, Song Q, Yao L, Pang Z, Jiang X, Chen H, Chen J.
Glioma therapy using tumor homing and penetrating peptide-functionalized PEG-PLA nanoparticles loaded withpaclitaxel.
Biomaterials . 2013 Jul;34(22):5640-50. (IF 10.273)
84. Ding G, Liu H, Wang Y, Lü Y, Wu Y, Guo Y, Xu L.
Fabrication of a magnetite nanoparticle-loaded polymeric nanoplatform for magnetically guided drug delivery.
Chemical Research in Chinese Universities . 2013 Feb;29(1):103-9. (IF 1.071)
85. Rasul A, Bao R, Malhi M, Zhao B, Tsuji I, Li J, Li X.
Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation andmitochondrial dysfunction.
Molecules . 2013 Jan 24;18(2):1418-33. (IF 3.06)
86. Mo R, Sun Q, Li N, Zhang C.
Intracellular delivery and antitumor effects of pH-sensitive liposomes based on zwitterionic oligopeptide lipids.
Biomaterials . 2013 Apr;34(11):2773-86. (IF 10.273)
87. Zhang X, Li G, Zhang L, Yang D, Zhang Z, Yan A, Linghu H.
C3G overexpression promotes the survival of rat-derived H9C2 cardiomyocytes via p-ERK1/2.
Cell Biol Int . 2013 Oct;37(10):1106-13. (IF 2.127)
88. Zhou Y, Lan J, Wang W, Shi Q, Lan Y, Cheng Z, Guan H.
ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma.
J Mol Histol . 2013 Oct;44(5):555-63. (IF 2.937)
89. Zhao C, Yin P, Mei C, Li N, Yao W, Li X, Qi J, Fan K, Li Z, Wang L, Shi Y, Qiu S, Fan J, Zha X.
Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in humanhepatocarcinoma cell lines.
Mol Cell Biochem . 2013 Apr;376(1-2):111-9. (IF 2.884)
90. Zhang Y, Wang H, Lai C, Wang L, Deng Y.
Comparative proteomic analysis of human SH-SY5Y neuroblastoma cells under simulated microgravity.
Astrobiology . 2013 Feb;13(2):143-50. (IF 3.768)
91. Liu L, Gu L, Ma Q, Zhu D, Huang X.
Resveratrol attenuates hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells.
EUR REV MED PHARMACO . 2013 Jan;17(1):88-94. (IF 2.721)
92. Zhang Y, Rasul A, Li XM, Malhi M, Fang XD,Wang L, Wang Y.
Lentivirus-mediated shRNA targeting decoy receptor 3 (DcR3) inhibits proliferation and augments apoptosis in pancreatic cancer Capan-1 cells.
AFR J PHARM PHARMACO . 2013 Feb;7(5):203-10. (IF 0.5)
93. Rasul A, Liu J, Liu Y, Millimouno FM, Wang X, Tsuji I, Yamamura T, Li J, Li XM.
Eriocalyxin B inhibits proliferation and induces apoptosis through downregulation of Bcl-2 and activation of caspase-3 in human bladder cancer cells.
Bangladesh Journal of Pharmacology .2013;8(2):116-23. (IF 0.811)
94. Wu W, Yang J, Feng X, Wang H, Ye S, Yang P, Tan W, Wei G, Zhou Y.
MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth,migration, and invasion in colorectal carcinoma cells.
Mol Cancer . 2013 Apr 23;12:30. (IF 10.679)
95. Chen Z, Rasul A, Zhao C, Millimouno FM.
Antiproliferative and apoptotic effects of pinocembrin in human prostate cancer cells.
Bangladesh Journal of Pharmacology .2013;8(3):255-262. (IF 0.811)
96. Zhang T, Yu H, Dong G, Cai L, Bai Y.
Chamaejasmine arrests cell cycle, induces apoptosis and inhibits nuclear NF-κB translocation in the humanbreast cancer cell line MDA-MB-231.
Molecules . 2013 Jan 11;18(1):845-58. (IF 3.06)
97. Wang B, Yu T, Dong X, Zhang Z, Song L, Xu Y, Zhang XH.
Edwardsiella tarda invasion of fish cell lines and the activation of divergent cell death pathways.
Vet Microbiol . 2013 May 3;163(3-4):282-9. (IF 2.791)
98. Li D, Ma H, Ye Y, Ji C, Tang X, Ouyang D, Chen J, Li Y, Ma Y.
Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway.
ENVIRON TOXICOL CHEM . 2014 Jul;38(1):163-71. (IF 3.421)
99. Yang ZY, Kan JT, Cheng ZY, Wang XL, Zhu YZ, Guo W.
Daphnoretin-induced apoptosis in HeLa cells: a possible mitochondria-dependent pathway.
Cytotechnology . 2014 Jan;66(1):51-61. (IF 1.672)
100. Yu XL, Jing T, Zhao H, Li PJ, Xu WH, Shang FF.
Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts.
ASIAN PAC J CANCER P  . 2014;15(3):1465-70. (IF 1.24)
101. He Y, Wang N, Shen Y, Zheng Z, Xu X.
Inhibition of high glucose-induced apoptosis by uncoupling protein 2 in human umbilical vein endothelial cells.
Int J Mol Med . 2014 May;33(5):1275-81. (IF 2.928)
102. Huang L, Huang QY, Huang HQ.
The evidence of HeLa cell apoptosis induced with tetraethylammonium using proteomics and various analytical methods.
J Biol Chem . 2014 Jan 24;289(4):2217-29. (IF 4.106)
103. Zhang Z, Li J, Yang L, Chen R, Yang R, Zhang H, Cai D, Chen H.
The cytotoxic role of intermittent high glucose on apoptosis and cell viability in pancreatic beta cells.
J Diabetes Res . 2014;2014:712781. (IF 3.04)
104. Feng Y, Ke C, Tang Q, Dong H, Zheng X, Lin W, Ke J, Huang J, Yeung SC, Zhang H.
Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.
Cell Death Dis . 2014 Feb 27;5:e1088. (IF 5.959)
105. Li CH, Wu DF, Ding H, Zhao Y, Zhou KY, Xu DF.
Berberine hydrochloride impact on physiological processes and modulation of twist levels in nasopharyngeal carcinoma CNE-1 cells.
ASIAN PAC J CANCER P  . 2014;15(4):1851-7. (IF 1.24)
106. Wu L, Li Q, Liu Y.
Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest.
J Pharm Pharmacol . 2014 May;66(5):713-21. (IF 2.39)
107. Hou Y, Lai M, Chen X, Li J, Hu Y, Luo Z, Ding X, Cai K.
Effects of mesoporous SiO2 , Fe3 O4 , and TiO2 nanoparticles on the biological functions of endothelial cells in vitro.
J Biomed Mater Res A . 2014 Jun;102(6):1726-36. (IF 3.221)
108. Xie Q, Yang Y, Wang Z, Chen F, Zhang A, Liu C.
Resveratrol-4-O-D-(2'-galloyl)-glucopyranoside isolated from Polygonum cuspidatum exhibits anti-hepatocellular carcinoma viability by inducing apoptosis via the JNK and ERK pathway.
Molecules . 2014 Jan 27;19(2):1592-602. (IF 3.06)
109. Liu K, Zhang G, Wang Z, Liu Y, Dong J, Dong X, Liu J, Cao J, Ao L, Zhang S.
The protective effect of autophagy on mouse spermatocyte derived cells exposure to 1800MHz radiofrequency electromagnetic radiation.
Toxicol Lett . 2014 Aug 4;228(3):216-24. (IF 3.499)
110. Liu Y, Li Z, Wu L, Wang Z, Wang X, Yu Y, Zhao Q, Luo F.
MiRNA-125a-5p: a regulator and predictor of gefitinib's effect on nasopharyngeal carcinoma.
Cancer Cell Int . 2014 Mar 7;14(1):24. (IF 3.439)
111. Cai H, Meng X, Li Y, Yang C, Liu Y.
Growth Inhibition Effects of Isoalantolactone on K562/A02 Cells: Caspase-dependent Apoptotic Pathways, S Phase Arrest, and Downregulation of Bcr/Abl.
Phytother Res . 2014 Nov;28(11):1679-86. (IF 3.766)
112. Ran Y, Wu H, Wei L, Yu X, Chen J, Li S, Zhang L, Lou J, Zhu D.
NFATc3 pathway participates in the process that 15-LO/15-HETE protects pulmonary artery smooth muscle cells against apoptosis during hypoxia.
J RECEPT SIG TRANSD . 2014 Aug;34(4):270-82. (IF 1.629)
113. Huyan T, Li Q, Yang H, Jin ML, Zhang MJ, Ye LJ, Li J, Huang QS, Yin DC.
Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells.
CARBOHYD POLYM . 2014 Jan 30;101:819-27. (IF 6.044)
114. Li Q, Liu T, Li Y, Luo S, Zhu Q, Zhang L, Zhao T.
Transport and killing mechanism of a novel camptothecin-deoxycholic acid derivate on hepatocellular carcinoma cells.
J Drug Target . 2014 Jul;22(6):543-52. (IF 3.277)
115. Li BH, Yin YW, Liu Y, Pi Y, Guo L, Cao XJ, Gao CY, Zhang LL, Li JC.
TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells.
Cell Death Dis . 2014 Apr 17;5:e1182. (IF 5.959)
116. Zhou Z, Liu Y, Qin M, Sheng W, Wang X, Li Z, Zhong R.
Depletion of PKM2 leads to impaired glycolysis and cell death in 2-demethoxy-2, 3-ethylenediamino hypocrellin B-photoinduced A549 cells.
J PHOTOCH PHOTOBIO B . 2014 May 5;134:1-8. (IF 4.067)
117. Qu J, Liu W, Huang C, Xu C, Du G, Gu A, Wang X.
Estrogen receptors are involved in polychlorinated biphenyl-induced apoptosis on mouse spermatocyte GC-2 cell line.
Toxicol In Vitro . 2014 Apr;28(3):373-80. (IF 3.067)
118. Wang N, Wang X, Yang C, Zhao X, Zhang Y, Wang T, Chen S.
Molecular cloning and multifunctional characterization of GRIM-19 (gene associated with retinoid-interferon-induced mortality 19) homologue from turbot (Scophthalmus maximus).
Dev Comp Immunol . 2014 Mar;43(1):96-105. (IF 3.119)
119. Yang R, Chen D, Li M, Miao F, Liu P, Tang Q.
20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres applied to HeLa cervical cancer cells in vitro.
BIO-MED MATER ENG . 2014 Jan 1;24(6):1991-8. (IF 0.993)
120. Fan Y, Chen M, Meng J, Yu L, Tu Y, Wan L, Fang K, Zhu W.
Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity.
PLoS One . 2014 Aug 21;9(8):e105890. (IF 2.776)
121. Li YJ, Huang P, Jiang CL, Jia de X, Du XX, Zhou JH, Han Y, Sui H, Wei XL, Liu L, Yuan HH, Zhang TT, Zhang WJ, Xie R, Lang XH, Wang LY, Liu T, Bai YX, Tian Y.
Sonodynamically Induced Anti-tumor Effect of 5-Aminolevulinic Acid on Pancreatic Cancer Cells.
Ultrasound Med Biol . 2014 Nov;40(11):2671-9. (IF 2.205)
122. Yang X, Zhu H, Ge Y, Liu J, Cai J, Qin Q, Zhan L, Zhang C, Xu L, Liu Z, Yang Y, Yang Y, Ma J, Cheng H, Sun X.
Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α.
TUMOR BIOL  . 2014 Jul 23;255-62. (IF 3.65)
123. Liang JX, Ning Z, Gao W, Ling J, Wang AM, Luo HF, Liang Y, Yan Q, Wang ZY.
Ubiquitin specific protease 22 induced autophagy is correlated with poor prognosis of pancreatic cancer.
Oncol Rep . 2014 Dec;32(6):2726-34. (IF 3.041)
124. Wang L, He S, Wu X, Liang S, Mu Z, Wei J, Deng F, Deng Y, Wei S.
Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties.
Biomaterials . 2014 Aug;35(25):6758-75. (IF 10.273)
125. Zhang R, Liu R, Wang W, Xin L, Wang L, Li C, Song L.
Identification and functional analysis of a novel IFN-like protein (CgIFNLP) in Crassostrea gigas.
FISH SHELLFISH IMMUN . 2015 Jun;44(2):547-54. (IF 3.298)
126. Qin B, Cao Y, Yang H, Xiao B, Lu Z.
MicroRNA-221/222 regulate ox-LDL-induced endothelial apoptosis via Ets-1/p21 inhibition.
Mol Cell Biochem . 2015 Jul;405(1-2):115-24. (IF 2.884)
127. Lan QY, Liu QL, Cai J, Liu AW.
3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one (CHP) inhibits human ovarian cell proliferation by inducing apoptosis.
INT J CLIN EXP PATHO . 2015 Jan 1;8(1):155-63. (IF 0.205)
128. Yang H, Mao Y, Tan B, Luo S, Zhu Y.
The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2.
Eur J Pharmacol . 2015 Aug 15;761:135-43. (IF 3.17)
129. Chen G, Qian W, Li J, Xu Y, Chen K.
Exopolysaccharide of Antarctic bacterium Pseudoaltermonas sp. S-5 induces apoptosis in K562 cells.
CARBOHYD POLYM . 2015 May 5;121:107-14. (IF 6.044)
130. Xu Y, Shen M, Sun Y, Gao P, Duan Y.
Polymer Nanocomposites Based Thermo-Sensitive Gel for Paclitaxel and Temozolomide Co-Delivery to Glioblastoma Cells.
J NANOSCI NANOTECHNO . 2015 Dec;15(12):9777-87. (IF 1.093)
131. Zhu Z, Song L, He J, Sun Y, Liu X, Zou X.
Ectopic expressed long non-coding RNA H19 contributes to malignant cell behavior of ovarian cancer.
INT J CLIN EXP PATHO . 2015 Sep 1;8(9):10082-91. (IF 0.205)
132. Dai J, Wu C, Muneri CW, Niu Y, Zhang S, Rui R, Zhang D.
Changes in mitochondrial function in porcine vitrified MII-stage oocytes and their impacts on apoptosis and developmental ability.
Cryobiology . 2015 Oct;71(2):291-8. (IF 2.141)
133. Wang Y, Ma L, Wang C, Sheng G, Feng L, Yin C.
Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells.
Int J Mol Med . 2015 Sep;36(3):627-32. (IF 2.928)
134. Liu Y, Liu Y, Bu W, Xiao Q, Sun Y, Zhao K, Fan W, Liu J, Shi J.
Radiation-/hypoxia-induced solid tumor metastasis and regrowth inhibited by hypoxia-specific upconversion nanoradiosensitizer.
Biomaterials . 2015 May;49:1-8. (IF 10.273)
135. Xie X, Yang Y, Lin W, Liu H, Liu H, Yang Y, Chen Y, Fu X, Deng J.
Cell-penetrating peptide-siRNA conjugate loaded YSA-modified nanobubbles for ultrasound triggered siRNA delivery.
COLLOID SURFACE B . 2015 Dec 1;136:641-50. (IF 3.973)
136. Li Q, Ye LJ, Ren HL, Huyan T, Li J, Shi JL, Huang QS.
Multiple effects of IL-21 on human NK cells in ex vivo expansion.
Immunobiology . 2015 Jul;220(7):876-88. (IF 2.798)
137. Ren X, Bai X, Zhang X, Li Z, Tang L, Zhao X, Li Z, Ren Y, Wei S, Wang Q, Liu C, Ji J.
Quantitative nuclear proteomics identifies that miR-137-mediated EZH2 reduction regulates resveratrol-induced apoptosis of neuroblastoma cells.
Mol Cell Proteomics . 2015 Feb;14(2):316-28. (IF 4.828)
138. Zha X, Wu G, Zhao X, Zhou L, Zhang H, Li J, Ma L, Zhang Y.
PRDX6 Protects ARPE-19 Cells from Oxidative Damage via PI3K/AKT Signaling.
CELL PHYSIOL BIOCHEM . 2015;36(6):2217-28. (IF 5.5)
139. Zhang R, Shi H, Ren F, Liu H, Zhang M, Deng Y, Li X.
Misregulation of polo-like protein kinase , P53 and P21WAF1 in epithelial ovarian cancer suggests poor prognosis.
Oncol Rep . 2015 Mar;33(3):1235-42. (IF 3.041)
140. Tang Y, Li J, Li F, Hu CA, Liao P, Tan K, Tan B, Xiong X, Liu G, Li T, Yin Y.
Autophagy protects intestinal epithelial Cells against Deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway.
FREE RADICAL BIO MED . 2015 Dec;89:944-51. (IF 5.657)
141. Mo M, Zhou M, Wang L, Qi L, Zhou K, Liu LF, Chen Z, Zu XB.
CCL21/CCR7 enhances the proliferation, migration, and invasion of human bladder cancer T24 cells.
PLoS One . 2015 Mar 23;10(3):e0119506. (IF 2.776)
142. Wang X, Diao Y, Liu Y, Gao N, Gao D, Wan Y, Zhong J, Jin G.
Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells.
Mol Med Rep . 2015 Sep;12(3):4750-8. (IF 1.851)
143. Guo L, Yang X, Lin X, Lin Y, Shen L, Nie Q, Ren L, Guo Q, Que S, Qiu Y.
Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
Behav Brain Res . 2015 Oct 1;292:528-36. (IF 2.77)
144. Lv Q, Yang XZ, Fu LY, Lu YT, Lu YH, Zhao J, Wang FJ.
Recombinant expression and purification of a MAP30-cell penetrating peptide fusion protein with higher anti-tumor bioactivity.
PROTEIN EXPRES PURIF . 2015 Jul;111:9-17. (IF 1.291)
145. Li H, Feng L, Jiang W, Liu Y, Jiang J, Zhang Y, Wu P, Zhou X.
Ca(2+) and caspases are involved in hydroxyl radical-induced apoptosis in erythrocytes of Jian carp (Cyprinus carpio var. Jian).
Fish Physiol Biochem . 2015 Oct;41(5):1305-19. (IF 1.729)
146. Ge H, Tan L, Wu P, Yin Y, Liu X, Meng H, Cui G, Wu N, Lin J, Hu R, Feng H.
Poly-L-ornithine promotes preferred differentiation of neural stem/progenitor cells via ERK signalling pathway.
SCI REP-UK . 2015 Oct 27;5:15535. (IF 4.011)
147. Li J, Lei H, Xu Y, Tao ZZ.
miR-512-5p suppresses tumor growth by targeting hTERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo.
PLoS One . 2015 Aug 10;10(8):e0135265. (IF 2.776)
148. Liu XL, Hu JY, Hu MY, Zhang Y, Hong ZY, Cheng XQ, Chen J, Pang DW, Liang Y.
Sequence-dependent abnormal aggregation of human Tau fragment in an inducible cell model.
BBA-BIOMEMBRANES . 2015 Aug;1852(8):1561-73. (IF 3.79)
149. Meng H, Wang K, Chen X, Guan X, Hu L, Xiong G, Li J, Bai Y.
MicroRNA-330-3p functions as an oncogene in human es